• Takeshi Hayashi, Yoshihide Seahara, Yuji Kato, Takuya Fukuoka, Ichiro Deguchi, Yasuko Ohe, Hajime Maruyama, Yohsuke Horiuchi, Hiroyasu Sano, Yuito Nagamine, and Norio Tanahashi.
• Department of Neurology and Cerebrovascular Medicine, Saitama Medical University, International Medical Center, Hidaka, Japan. Electronic address: thayashi@saitama-med.ac.jp.
• J Stroke Cerebrovasc Dis. 2014 Sep 1;23(8):2169-73.

BackgroundPrevious studies show that 6%-31% of transient ischemic attacks (TIA) were caused by cardiogenic cerebral embolism (cardioembolic TIA). As prompt initiation of therapy is essential in TIA to prevent subsequent strokes, determining their cause is important. In this study, we aim to determine the features of cardioembolic TIA and to compare them with those of noncardioembolic etiology.MethodsWe retrospectively reviewed patients with a tissue-defined TIA who were admitted to our hospital from April 2007 to August 2013. The etiology was categorized according to Trial of Org 10172 in Acute Stroke Treatment, and TIA of cardioembolic origin and cervicocerebrovascular etiology (noncardioembolic TIA) were included in this study. Those with 2 or more possible causes or undetermined etiologies were excluded. Age, sex, comorbidities, ABCD2 score, and CHADS2 score were assessed and compared between the 2 groups.ResultsThere were no significant differences in the neurologic symptoms and their duration, morbidities of hypertension, diabetes, and dyslipidemia between the 2 groups. Coronary and peripheral artery diseases were more common in the cardioembolic TIA group (18.4% vs. 6.9%). Incidences of prior stroke and cerebral infarction determined by MRI were similar between the 2 groups. The ABCD2 score showed a similar distribution, but the CHADS2 score was significantly different; the cardioembolic TIA group showed a higher score (P = .005).ConclusionsClinical features are similar in tissue-defined TIA of cardioembolic and noncardioembolic etiologies. The CHADS2 score can be useful in assessing the probability of cardioembolic TIA.Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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