• Contemp Top Lab Anim Sci · Mar 2001

    Comparative Study

    The effect of brief halothane anesthesia during daily gavage on complications and body weight in rats.

    • S J Murphy, P Smith, A B Shaivitz, M I Rossberg, and P D Hurn.
    • Johns Hopkins Medical Institutions, Department of Anesthesiology and Critical Care Medicine, 600 North Wolfe Street, Blalock 1408, Baltimore, Maryland 21287, USA.
    • Contemp Top Lab Anim Sci. 2001 Mar 1;40(2):9-12.

    AbstractWe examined retrospectively the effects of brief halothane anesthesia during daily gavage administration of vehicle on gavage-related complications and body weight in ovariectomized female Wistar rats. The number of gavage-related deaths or animals requiring euthanasia due to gavage problems was dramatically reduced, but the occurrence of incomplete vehicle retention during gavage was increased appreciably in halothane-anesthetized animals. Halothane-anesthetized rats maintained daily body weight for a longer period than did awake animals. Our observations suggest that the use of brief inhalational anesthesia reduces gavage-associated death and euthanasia due to esophageal trauma and minimizes stress-related weight loss.

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