Diffuse correlation spectroscopy for non-invasive,

NeuroImage · Jan 2014

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Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement.

Diffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli.

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- Turgut Durduran and Arjun G Yodh.
- ICFO- Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain. Electronic address: turgut.durduran@icfo.es.
- Neuroimage. 2014 Jan 15;85 Pt 1:51-63.
AbstractDiffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli.Copyright © 2013 Elsevier Inc. All rights reserved.

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Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement.

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