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- D Schaps, H Striebel, J Zuk, and W Seitz.
- Anaesthesist. 1984 May 1;33(5):228-34.
AbstractIn 93 patients (ASA I) undergoing orthopaedic operations respiratory and haemodynamic effects of alfentanil (steady state: spontaneous breathing halothane, N2O/O2) were measured. After injection of alfentanil apnoea was found be readily antagonized by Naloxone. A significant decrease of arterial pressure and heart rate occurred simultaneously independent of dose level. The decrease of arterial pressure could be prevented by pre-injection of atropine. Therefore an increased vagal tone must be responsible for depression of haemodynamic parameters.
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