• Ulus Travma Acil Cer · Jan 2013

    Medicinal plant extract (Ankaferd Blood Stopper) application in deep tissue injuries in rats: histopathological investigation of the effect on regional and systemic tissues.

    • Mehmet Okumuş, Kasım Zafer Yüksel, Davut Özbağ, Harun Çıralık, Zeki Yılmaz, Yakup Gümüşalan, Vedat Bakan, and Ali Murat Kalender.
    • Department of Emergency Medicine, Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. okumus@hotmail.com
    • Ulus Travma Acil Cer. 2013 Jan 1;19(1):1-7.

    BackgroundThis study was planned to evaluate both the histopathological changes under light microscope as well as the systemic organ effects following application of Ankaferd Blood Stopper® (ABS) (a mixture of five plant extracts) in an animal model of deep tissue hemorrhage.MethodsA total of 50 Wistar Albino rats were divided into five groups of 10 rats each. The rats underwent femoral vein puncture and were treated with ABS tampon, ABS spray, or Surgicel, and one group was left untreated. After two weeks, each group underwent partial tissue excision from the same femoral region as well as from the brain, heart, kidney, and liver.ResultsThe specimens from all groups were obtained from the femoral region after two weeks and evaluated under light microscope. The light microscope revealed no histopathological changes in neurovascular structures or in deep connective tissues in any of the groups.ConclusionABS provided hemostasis and was observed to stop bleeding. There were no histopathological changes at the tissue level and no pathological effects in other organs tissues under light microscope, and the remote organ tissue remained clear.

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