• Int J Chron Obstruct Pulmon Dis · Jan 2015

    Amoxicillin concentrations in relation to beta-lactamase activity in sputum during exacerbations of chronic obstructive pulmonary disease.

    • Marjolein Brusse-Keizer, Paul VanderValk, Rogier W van der Zanden, Lars Nijdam, Job van der Palen, Ron Hendrix, and Kris Movig.
    • Medical School Twente, Medisch Spectrum Twente, Enschede, the Netherlands.
    • Int J Chron Obstruct Pulmon Dis. 2015 Jan 1;10:455-61.

    BackgroundAcute exacerbations of chronic obstructive pulmonary disease (COPD) are often treated with antibiotics. Theoretically, to be maximally effective, the antibiotic concentration at sites of infection should exceed the minimum inhibitory concentration at which 90% of the growth of potential pathogens is inhibited (MIC90). A previous study showed that most hospitalized COPD patients had sputum amoxicillin concentrations MethodsIn total, 23 patients hospitalized for acute exacerbations of COPD and treated with amoxicillin/clavulanic acid were included. Sputum and serum samples were collected at day 3 of treatment to determine beta-lactamase activity in sputum and amoxicillin concentrations in both sputum and serum.ResultsWe found no difference in beta-lactamase activity between patients with sputum amoxicillin concentrations ConclusionIn patients treated with amoxicillin/clavulanic acid for an acute exacerbation of COPD, sputum beta-lactamase activity did not differ between those with sputum amoxicillin concentrations

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