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Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Jun 2000
[Effect of propofol and etomidate for anesthesia induction on plasma total cortisol concentration].
- Y Zhang, A Luo, G An, and Y Huang.
- Department of Anesthesiology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. zhangyajun@hotmail.com
- Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun 1;22(3):284-6.
ObjectiveTo investigate the effect of propofol and etomidate for anesthesia induction on adrenocortical function.MethodsThe plasma total cortisol concentration was determined in 20 patients who were treated with propofol or etomidate.ResultsAfter propofol induction, the plasma total cortisol level decreased from (308.7 +/- 27.4) nmol/L to (267.7 +/- 31.2) nmol/L at post-medication 2 hours, increased to (400.2 +/- 26.9) nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours [(306.4 +/- 35.4) nmol/L]. After etomidate induction, the plasma total cortisol level decreased from (309.1 +/- 36.6) nmol/L to (115.9 +/- 29.7) nmol/L at postmedication 2 hours, maintained (171.1 +/- 34.7) nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours [(311.8 +/- 46.2) nmol/L].ConclusionsPropofol induction has little effect on adrenocortical function whereas etomidate induction inhibits adrenocortical function.
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