• Ismet Topçu, Gül Gümüşer, Eda Bayram, Feray Aras, Ismail Cetin, Cüneyt Temiz, and Melek Civi.
• Department of Anesthesiology and Intensive Care, Celal Bayar University Faculty of Medicine, Manisa, Turkey. topcuismet@yahoo.com
• Ulus Travma Acil Cer. 2013 Jul 1;19(4):294-8.

BackgroundIn this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied.MethodsTwenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg-1 lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method.ResultsThe lesion/background (L/b) ratio of Group I was 3.76±0.46 and 3.02±0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52±0.96 and 2.63±0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6±2.5% and 77.5±1.1% for Groups I and II, respectively (p<0.05).ConclusionIn this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.

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