• Okay Koç, Ahmet Dağ, Ahmet Koray Ocal, Mustafa Musa Dirlik, Ulkü Cömelekoğlu, Lülüfer Tamer Gümüş, Ebru Serinsöz, Emine Arzu Kanık, and Hamdi Akça.
• Department of Gastroenterologic Surgery, Diyarbakır Training and Research Hospital, Diyarbakır, Turkey. okaykocdr@yahoo.com.tr
• Ulus Travma Acil Cer. 2013 Jul 1;19(4):305-12.

BackgroundWe aimed to introduce the efficiency of 4% icodextrin solution on preventing adhesions and its effect on anastomotic healing, together with biochemical parameters.MethodsIn total, 40 rats were divided into four groups of 10 rats each as Group A (abrasion+icodextrin), Group B (abrasion), Group C (anastomosis+icodextrin), and Group D (anastomosis). Adhesion grade, anastomotic bursting pressure, histopathological analysis, tissue hydroxyproline level, and serum myeloperoxidase (MPO), nitric oxide (NO), and malondialdehyde (MDA) values were examined.ResultsAdhesion score was significantly lower in Group A than in Group B and significantly lower in Group C than in Group D (p=0.003577, p=0.001612). No difference in anastomoses healing was determined between Group C and Group D (p=0.816). Hydroxyproline level was significantly higher in Group A than in Group B and significantly higher in Group C than in Group D (p=0.001, p=0.0001). There were no differences in NO and MDA levels between Group A and Group B, but values were significantly lower in Group C than in Group D (p=0.434, p=0.001, p=0.116, p=0.018). MPO level was significantly lower in Group A than in Group B and significantly lower in Group C than in Group D (p=0.0001, p=0.0001).ConclusionBased on our results, 4% icodextrin solution evidently decreased the formation of adhesion without negatively affecting the anastomotic healing. We also reported herein the biochemical and histopathological results and adhesion scores.

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