• Andrew Close, Clare Robertson, Stephen Rushton, Mark Shirley, Luke Vale, Craig Ramsay, and Robert Pickard.
• School of Biology, Newcastle University, Newcastle upon Tyne, UK.
• Eur. Urol. 2013 Sep 1;64(3):361-9.

BackgroundRobot-assisted laparoscopic prostatectomy is increasingly used compared with a standard laparoscopic technique, but it remains uncertain whether potential benefits offset higher costs.ObjectiveTo determine the cost-effectiveness of robotic prostatectomy.Design, Setting, And ParticipantsWe conducted a care pathway description and model-based cost-utility analysis. We studied men with localised prostate cancer able to undergo either robotic or laparoscopic prostatectomy for cure. We used data from a meta-analysis, other published literature, and costs from the UK National Health Service and commercial sources.Outcome Measurements And Statistical AnalysisCare received by men for 10 yr following radical prostatectomy was modelled. Clinical events, their effect on quality of life, and associated costs were synthesised assuming 200 procedures were performed annually.Results And LimitationsOver 10 yr, robotic prostatectomy was on average (95% confidence interval [CI]) £1412 (€1595) (£1304 [€1473] to £1516 [€1713]) more costly than laparoscopic prostatectomy but more effective with mean (95% CI) gain in quality-adjusted life-years (QALYs) of 0.08 (0.01-0.15). The incremental cost-effectiveness ratio (ICER) was £18 329 (€20 708) with an 80% probability that robotic prostatectomy was cost effective at a threshold of £30 000 (€33 894)/QALY. The ICER was sensitive to the throughput of cases and the relative positive margin rate favouring robotic prostatectomy.ConclusionsHigher costs of robotic prostatectomy may be offset by modest health gain resulting from lower risk of early harms and positive margin, provided >150 cases are performed each year. Considerable uncertainty persists in the absence of directly comparative randomised data.Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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