• Bmc Musculoskel Dis · Jan 2006

    No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study.

    • Knut Hagen, Elin Pettersen, Lars Jacob Stovner, Frank Skorpen, and John-Anker Zwart.
    • Department of Clinical Neuroscience; Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no
    • Bmc Musculoskel Dis. 2006 Jan 1;7:40.

    BackgroundThe Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype.MethodsIn the 1995-97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals.ResultsThe distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups.ConclusionIn this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.

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