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- Gunilla Leander, Erik Eliasson, Håkan Hanberger, and Christian Giske.
- - Infektionskliniken Karlskrona, Sweden - Infektionskliniken Karlskrona, Sweden.
- Lakartidningen. 2015 Jan 1;112.
AbstractPatients with severe sepsis/septic shock have a high mortality. Beta-lactam antibiotics are normally first line treatment. This antimicrobial class has been associated with time-dependent efficacy. It is therefore plausible that administration as prolonged infusion will increase the therapeutic effect, as compared to short term bolus injections, which is the most common practice today. We have reviewed 14 randomized controlled studies to investigate whether prolonged infusion provides lower mortality and/or increased clinical cure. In summary, convincing advantages with prolonged infusion could not be found, however randomized studies are heterogeneous, and it cannot be excluded that some subgroups of critically ill patients could benefit from such treatment.
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