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Randomized Controlled Trial Comparative Study Clinical Trial
Amoxicillin-clavulanate prophylaxis against wound infections after clean-contaminated surgery. A controlled, randomized, prospective study.
- A Weersink, M Visser, A Vos, P Hulstaert, I ten Berge, M Muijsken, T van Vroonhoven, and J Verhoef.
- Department of Clinical Microbiology, University Hospital, Utrecht, The Netherlands.
- Eur J Surg. 1991 Apr 1;157(4):271-5.
AbstractIn a single-blind, prospective randomized and controlled trial, amoxicillin-clavulanate was compared with gentamicin plus clindamycin as perioperative prophylaxis for 24 hours in clean-contaminated abdominal surgery. Proven infections of the abdominal incision occurred in one of 59 evaluable patients given amoxicillin-clavulanate and one of 43 with gentamicin/clindamycin. In the latter group there was also one incisional perineal wound infection. At follow-up enquiry by telephone around postoperative day 30, four patients in the amoxicillin-clavulanate group reported minor wound discharge for which they had not sought medical attention. Intraperitoneal infection occurred in one patient of that group, and in three of the gentamicin/clindamycin group. Both regimens thus were effective and safe as prophylaxis in clean-contaminated abdominal surgery.
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