• Farrah J Mateen, Rajanandini Muralidharan, Russell T Shinohara, Joseph E Parisi, Gregory J Schears, and Eelco F M Wijdicks.
• Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA. fmateen@jhsph.edu
• Arch. Neurol. 2011 Dec 1;68(12):1543-9.

BackgroundExtracorporeal membrane oxygenation (ECMO) may be urgently used as a last resort form of life support when all other treatment options for potentially reversible cardiopulmonary injury have failed.ObjectiveTo examine the range and frequency of neurological injury in ECMO-treated adults.DesignRetrospective clinicopathological cohort study.SettingMayo Clinic, Rochester, Minnesota.PatientsA prospectively collected registry of all patients 15 years or older treated with ECMO for 12 or more hours from January 2002 to April 2010.InterventionPatients were analyzed for potential risk factors for neurological events and death using logistic regression and Cox proportional hazards models.Main Outcome MeasuresNeurological diagnosis and/or death.ResultsA total of 87 adults were treated (35 female [40%]; median age, 54 years [interquartile range, 31]; mean duration of ECMO, 91 hours [interquartile range, 100]; overall survival >7 days after ECMO, 52%). Neurological events occurred in 42 patients who received ECMO (50%; 95% confidence interval [CI], 39%-61%). Diagnoses included subarachnoid hemorrhage, ischemic watershed infarctions, hypoxic-ischemic encephalopathy, unexplained coma, and brain death. Death in patients who received ECMO who did not require antecedent cardiopulmonary resuscitation was associated with increased age (odds ratio, 1.24 per decade; 95% CI, 1.03-1.50; P = .02) and lower minimum arterial oxygen pressure (odds ratio, 0.79; 95% CI, 0.68-0.92; P = .03). Although stroke was rarely diagnosed clinically, 9 of 10 brains studied at autopsy demonstrated hypoxic-ischemic and hemorrhagic lesions of vascular origin.ConclusionSevere neurological sequelae occur frequently in adult ECMO-treated patients with otherwise reversible cardiopulmonary injury (conservative estimate, 50%) and include a range of potentially fatal neurological diagnoses that may be due to the precipitating event and/or ECMO treatment.

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