• Am. J. Gastroenterol. · May 2013

    Randomized Controlled Trial

    A randomized controlled trial of an online intervention to improve gluten-free diet adherence in celiac disease.

    • Kirby Sainsbury, Barbara Mullan, and Louise Sharpe.
    • Clinical Psychology Unit, The University of Sydney, Sydney, New South Wales, Australia.
    • Am. J. Gastroenterol. 2013 May 1;108(5):811-7.

    ObjectivesTo test the effectiveness of an interactive online intervention to improve gluten free diet adherence in adults with celiac disease.MethodsA Randomized controlled trial was conducted. A total of 189 adults with biopsy-confirmed celiac disease were recruited and randomized to receive the intervention (n=101) or to a waitlist control condition (n=88). Post-intervention data was available for 70 intervention and 64 waitlist participants. Three month follow-up data was obtained for 46/50 completers from the intervention group. The primary outcome measure was gluten-free diet adherence. Secondary outcomes were gluten-free diet knowledge, quality of life and psychological symptoms.ResultsResults were based on intention-to-treat analyses. The intervention group evidenced significantly improved gluten-free diet adherence, and gluten-free diet knowledge following the treatment period relative to the waitlist control group. The change in knowledge did not contribute to the change in adherence. These improvements were maintained at 3-month' follow-up.ConclusionsThe online program was effective in improving adherence and represents a promising resource for individuals with celiac disease who are struggling to achieve or maintain adequate gluten free diet adherence.

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