• J Comput Assist Tomogr · Sep 1991

    Case Reports

    SPECT and MR imaging in herpes simplex encephalitis.

    • M Schmidbauer, I Podreka, D Wimberger, W Oder, G Koch, S Wenger, G Goldenberg, S Asenbaum, and L Deecke.
    • Abteilung für Neuronuklearmedizin, Neuronuklearmedizin der Neurologischen Universitätsklinik Wien, Austria.
    • J Comput Assist Tomogr. 1991 Sep 1;15(5):811-5.

    AbstractTwo cases of necrotizing herpes simplex encephalitis (HSE) were investigated with 99mTc-hexamethylpropyleneamineoxime (HMPAO) SPECT and MR. The clinical course was compared with the neuroimaging results. In the acute stage, the increased HMPAO uptake matched the MR hyperintense signal in the limbic temporal lobe and in the basal ganglia. Protracted inflammation was accompanied by persistently high HMPAO uptake. The sequelae of HSE were characterized by decreased HMPAO uptake and postnecrotic widening of the temporal horns. The "limbic" pattern recognized in both SPECT and MR reflects the basic pathophysiology and neuropathology of HSE. Both methods may be useful in the diagnosis and follow-up of HSE.

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