• Pediatr. Nephrol. · Oct 2011

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    Should we consider MMF therapy after rituximab for nephrotic syndrome?

    • Guido Filler, Shih-Han Susan Huang, and Ajay P Sharma.
    • Department of Pediatrics, Schulich School of Medicine & Dentistry, London, ON, Canada, N6A 5W9. guido.filler@lhsc.on.ca
    • Pediatr. Nephrol. 2011 Oct 1;26(10):1759-62.

    AbstractThe management of steroid-dependent nephrotic syndrome, especially in patients who have failed to respond to cytotoxic drugs, such as cyclophosphamide, remains challenging. Rituximab represents a new (off-label) therapeutic option. In a significant portion of patients, it has a short serum half-life following the recovery of CD20-positive cells. The addition of mycophenolate mofetil (MMF) as a maintenance therapy is also an attractive option, but one which requires testing in a prospective randomized clinical trial with therapeutic drug monitoring and mechanistic ancillary studies.

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