• Onur Polat, Gurur Polat, Sercin Karahuseyinoglu, Nüket Yörür Kutlay, Arzu Gül Tasci, Esra Erdemli, Ajlan Tukun, Mustafa Cihat Avunduk, Sükrü Küplülü, and Mehmet Demirtas.
• Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine Ankara, Sihhiye, Turkey. onurpolat1971@yahoo.com.
• Eur J Trauma Emerg S. 2010 Feb 1;36(1):60-6.

BackgroundFracture healing is a significant process in orthopedics. In this controlled animal study, our aimis to expose the healing effects of cord blood umbilico-placental mononuclear cells (UPMNCs) on bone fractures.Materials And MethodsCaesarean sections were performed on five pregnant New Zealand rabbits at term. Placentas and cords were collected. Standard closed transverse shaft fractures were created on both tibial bones of 15 baby rabbits. The right tibias were given UPMNCs; the left tibias were the control group. Histological examinations, osteoblast and osteoclast cell counts, and mechanical stabilities were compared. Anchorage of the donor cells was shown by the fluorescence in situ hybridization (FISH) technique.ResultsIn the group injected with UPMNCs, histopathological fracture healing was faster, osteoblast and osteoclast counts were significantly increased, and the maximum load capacity was higher. The presence of XX and XY chromatins on the same slide revealed the anchorage of female donor cells on male tissues.ConclusionThe effects of umbilico-placental mononuclear cells on bone healing are histopathological healing priority, increased osteoblastic and osteoclastic activities (bone turnover), and better mechanical stability.

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