• Mythili Srinivasan, Michael Turmelle, Leanne M Depalma, Jingnan Mao, and Douglas W Carlson.
• Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA. srinivasan_m@kids.wustl.edu
• J. Pediatr. 2012 May 1;160(5):801-806.e1.

ObjectiveTo evaluate the nature, frequency, and predictors of adverse events during the use of propofol by pediatric hospitalists.Study DesignWe reviewed 1649 charts of patients sedated with propofol by pediatric hospitalists at St Louis Children's Hospital between January 2005 and September 2009.ResultsHospitalists were able to complete 1633 of the 1649 sedations reviewed (99%). Major complications included 2 patients with aspiration and 1 patient intubated to complete the study. We observed a 74% reduction in the number of patients with respiratory events and airway interventions from 2005 to 2009. Predictors of respiratory events were history of snoring (OR, 2.40; 95% CI, 1.52-3.80), American Society of Anesthesiologists (ASA) physical status classification of ASA 3 (OR, 2.30; 95% CI, 1.22-4.33), age >12 years (OR, 4.01; 95% CI, 2.02-7.98), premedication with midazolam (OR, 1.85; 95% CI, 1.15-2.98), and use of adjuvant glycopyrrolate (OR, 4.70; 95% CI, 2.35-9.40). All except ASA 3 status were also predictors for airway intervention. There was a decline in the prevalence of all of these predictors over the study years (P < .05) except for use of glycopyrrolate.ConclusionOur pediatric hospitalists implemented a successful propofol sedation program that realized a 74% reduction in respiratory events and airway interventions between 2005 and 2009. Decreased prevalence of the predictors of adverse events that we identified likely contributed to this reduction.Copyright © 2012 Mosby, Inc. All rights reserved.

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