• Hong-ying Li, Jue Ma, Zhen Li, Wei-tao Ma, Wei Yu, and Guo-dong Zhao.
• Department of Anesthesiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China. leehyys@163.com
• Nan Fang Yi Ke Da Xue Xue Bao. 2009 Dec 1;29(12):2446-8.

ObjectiveTo investigate the effect of pentoxifylline on one-lung ventilation injury in rabbits.MethodsTwenty rabbit models of one-lung ventilation by intrabronchial intubation after tracheotomy were randomly allocated in control group (with one-lung ventilation) and experiment group (with one-lung ventilation and intravenous pentoxifylline administration). One-lung ventilation was maintained for 3 h in both groups using the volume-control mode (tidal volume of 8 ml/kg at the frequency of 30 per min). Arterial blood samples were taken after anesthesia and at 3 h of one-lung ventilation for arterial blood gas analysis to obtain the oxygenation index. At the end of the experiment, the pulmonary wet/dry ratio (W/D), tumor necrosis factor-alpha (TNF-alpha), NO, malondialdehyde (MDA) and superoxide dismutase (SOD) contents in bronchoalveolar lavage fluid (BALF) were measured and the histological appearance of the lung tissue was observed.ResultsThe oxygenation index was significantly higher (P<0.05), W/D ratio lower (P<0.05), and contents of TNF-alpha, NO and MAD in the BALF lower in the experimental group than in the control group (P<0.05). The activity of SOD increased significantly in the experimental group as compared with the control group (P<0.01), and the rabbits in the experimental group showed milder pathological changes.ConclusionIntravenous pentoxifylline may improve pulmonary ventilation function and alleviate pulmonary injury, thus offering protection against pulmonary injury after one-lung ventilation.

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