• Davood Ommi, Houman Teymourian, Alireza Zali, Farzad Ashrafi, Morteza Jabbary Moghaddam, and Alireza Mirkheshti.
• Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
• Anesth Pain Med. 2015 Aug 1;5(4):e23626.

BackgroundOpium is an addictive agent and one of the most common narcotics With great challenges of intraoperative hemodynamic instabilities.ObjectivesThe current study aimed to assess the effects of clonidine on intraoperative blood loss in patients with and without opium addiction in femoral fracture surgeries.Patients And MethodsIn a randomized clinical trial, 160 candidates for elective femoral fracture operations under general anesthesia were divided into four groups of 40 subjects: group 1 (placebo 1), subjects without addiction received placebo 90 minutes before the operation; group 2 (placebo 2), patients with opium addiction received placebo as group 1; group 3 (Clonidine 1), patients without addiction received clonidine 90 minutes before the operation and group 4 (Clonidine 2), patients with opium addiction received clonidine as premedication.ResultsIntraoperative blood loss in clonidine recipient groups, patients with and without addiction, was less than that of the placebos (both P values < 0.01) and the difference magnitude was higher in patients with opium addiction.ConclusionsPremedication with clonidine to decrease intraoperative blood loss can be more effective in patients with opium addiction than the ones without addiction.

4 keywords...

hide…