• Denise A Otsuki, Denise T Fantoni, Carla Holms, and Jose Otavio C Auler.
• Laboratory of Medical Investigation, LIM/08 Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
• Clinics (Sao Paulo). 2010 May 1;65(5):531-7.

BackgroundOriginal sevoflurane (Sevo A) is made with water, while a generic sevoflurane (Sevocris) is produced with propylene glycol as a stabilizing additive. We investigated whether the original and generic sevoflurane preparations differed in terms of their minimum alveolar concentration (MAC) values and hemodynamic effects.MethodsSixteen pigs weighing 31.6+/-1.8 kg were randomly assigned to the Sevo A or Sevocris groups. After anesthesia induction via mask with the appropriate sevoflurane preparation (6% in 100% oxygen), the MAC was determined for each animal. Hemodynamic and oxygenation parameters were measured at 0.5 MAC, 1 MAC and 1.5 MAC. Histopathological analyses of lung parenchyma were performed.ResultsThe MAC in the Sevo A group was 4.4+/-0.5%, and the MAC in the Sevocris group was 4.1+/-0.7%. Hemodynamic and metabolic parameters presented significant differences in a dose-dependent pattern as expected, but they did not differ between groups. Cardiac indices and arterial pressures decreased in both groups when the sevoflurane concentration increased from 0.5 to 1 and 1.5 MAC. The oxygen delivery index (DO(2)I) decreased significantly at 1.5 MAC.ConclusionPropylene glycol as an additive for sevoflurane seems to be as safe as a water additive, at least in terms of hemodynamic and pulmonary effects.

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