• Yannick Béjot, Corine Aboa-Eboulé, Stéphanie Debette, Alessandro Pezzini, Turgut Tatlisumak, Stefan Engelter, Caspar Grond-Ginsbach, Emmanuel Touzé, Maria Sessa, Tiina Metso, Antti Metso, Manja Kloss, Valeria Caso, Jean Dallongeville, Philippe Lyrer, Didier Leys, Maurice Giroud, Massimo Pandolfo, Shérine Abboud, and CADISP Group.
• From the Department of Neurology, Dijon University Hospital, Dijon, France (Y.B., C.A.-E., M.G.); Department of Epidemiology and Public Health, Inserm U744, Pasteur Institute, Lille, France (S.D., J.D.); Department of Neurology, EA1046, Lille University Hospital, Lille, France (S.D., D.L.); Department of Clinical and Experimental Sciences, Neurology Clinic, Brescia University Hospital, Brescia, Italy (A.P.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (T.T., T.M., A.M.); Department of Neurology, University Hospital of Basel, Basel, Switzerland (S.E., P.L.); Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany (C.G.-G., M.K.); Department of Neurology, Sainte-Anne University Hospital, Paris, France (E.T.); Department of Neurology, San Raffaele University Hospital, Milan, Italy (M.S.); Stroke Unit, Perugia University Hospital, Italy (V.C.); and Laboratory of Experimental Neurology, Université Libre de Bruxelles, Brussels, Belgium (M.P., S.A.).
• Stroke. 2014 Jan 1;45(1):37-41.

Background And PurposeLittle is known about factors contributing to multiple rather than single cervical artery dissections (CeAD) and their associated prognosis.MethodsWe compared the baseline characteristics and short-term outcome of patients with multiple to single CeAD included in the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study.ResultsAmong the 983 patients with CeAD, 149 (15.2%) presented with multiple CeAD. Multiple CeADs were more often associated with cervical pain at admission (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.10-2.30), a remote history of head or neck surgery (OR, 1.87; 95% CI, 1.16-3.00), a recent infection (OR, 1.71; 95% CI, 1.12-2.61), and cervical manipulation (OR, 2.23; 95% CI, 1.26-3.95). On imaging, cervical fibromuscular dysplasia (OR, 3.97; 95% CI, 2.04-7.74) and the presence of a pseudoaneurysm (OR, 2.91; 95% CI, 1.86-4.57) were more often seen in patients with multiple CeAD. The presence of multiple rather than single CeAD had no effect on functional 3-month outcome (modified Rankin Scale score, ≥3; 12% in multiple CeAD versus 11.9% in single CeAD; OR, 1.20; 95% CI, 0.60-2.41).ConclusionsIn the largest published series of patients with CeAD, we highlighted significant differences between multiple and single artery involvement. Features suggestive of an underlying vasculopathy (fibromuscular dysplasia) and environmental triggers (recent infection, cervical manipulation, and a remote history of head or neck surgery) were preferentially associated with multiple CeAD.

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