• S. Afr. Med. J. · Aug 1975

    Comparative Study Clinical Trial Controlled Clinical Trial

    Intravenous ketamine for postoperative analgesia.

    • L Clausen, D M Sinclair, and C H Van Hasselt.
    • S. Afr. Med. J. 1975 Aug 16;49(35):1437-40.

    AbstractThirty-six consecutive patients who had undergone major surgery were carefully studied for 6 hours postoperatively in an attempt to evaluate the relative analgesic and respiratory-depressant effect of morphine, ketamine, and placebo administered by continuous intravenous infusion. Side-effects, vital signs and respiratory measurements were recorded hourly by a consultant physician. With regard to the dosage and method of administration, ketamine was shown to be less effective than morphine for the first 3 hours postoperatively, but equally effective subsequently, whereas the patients who received ketamine showed a greater progressive tendency for their respiratory parameters to improve with time. Recommendations regarding the postoperative control of pain are made, and the need for further study is noted.

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