• Chemotherapy · Jan 2006

    Comparative Study

    Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.

    • Branka Bedenic, Marijana Topic, Ana Budimir, and Marina Bubonja.
    • Department of Microbiology, Medical School, University of Zagreb, Zagreb, Croatia. branka.bedenic@zg.htnet.hr
    • Chemotherapy. 2006 Jan 1;52(6):293-7.

    BackgroundIn this investigation, the urine samples obtained in a single oral-dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant urinary tract pathogens.MethodsSix healthy volunteers received a single oral dose of ten oral antibiotics available in Croatia. Urine samples were taken every 2 h during the whole dosing interval of the particular antibiotic. The urinary bactericidal activity was tested by determination of urinary bactericidal titers.ResultsAll antibiotics showed a significant urinary bactericidal activity against non-extended spectrum beta-lactamase Escherichia coli and Proteus mirabilis. Fluoroquinolones displayed high and persisting levels of urinary bactericidal activity against all gram-negative bacteria and Staphylococcus saprophyticus.ConclusionsAverage urinary bactericidal activity can be predicted from in vitro susceptibility testing, but we expect that there will be patients with a low level of urinary bactericidal activity.

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