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Methods Find Exp Clin Pharmacol · Dec 2010
Inhibitory effect of hydrocortisone on cerebral salt wasting after subarachnoid hemorrhage in rats.
- M Yoneko, Y Katayama, N Moro, J Kamei, and J Kojima.
- Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. xza04623@nifty.com
- Methods Find Exp Clin Pharmacol. 2010 Dec 1;32(10):727-31.
AbstractCerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, reduces total blood volume, aggravates cerebral vasospasm and causes cerebral ischemia after SAH. This study examined the inhibitory effect of hydrocortisone on CSW in rat SAH models. Hydrocortisone had an inhibitory effect on CSW because hydrocortisone functioned in a dose-dependent manner to inhibit the increase in sodium excretion and sodium/potassium ratio after SAH onset. We conclude that hydrocortisone is a useful drug for the treatment of CSW after SAH.Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
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