• Asian Pac J Allergy · Dec 1996

    Allergic reactions to phenytoin in a general hospital in Singapore.

    • K P Leong and H H Chng.
    • Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
    • Asian Pac J Allergy. 1996 Dec 1;14(2):65-8.

    AbstractPhenytoin is used for the treatment and prevention of fits. We investigated all patients reported to have phenytoin allergy in our hospital and found 42 confirmed cases. Sixty-nine percent were female and 83.3% were Chinese. The mean age of the patients was 46.5 years. The reactions reported were maculopapular rash (71.4%), Stevens-Johnson syndrome (14.3%), fever (4.8%), generalized exfoliative dermatitis (2.4%), toxic epidermal necrolysis (2.4%), vasculitis (2.4%) and agranulocytosis (2.4%). In conclusion, the majority of reported allergic reactions to phenytoin were cutaneous (92.9%) and one fifth of these were potentially life-threatening.

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