• G M Calori, E Mazza, M Colombo, S Mazzola, G V Mineo, and P V Giannoudis.
• Orthopaedic Reparative Surgery Department, Orthopaedic Institute Gaetano Pini, University of Milan, Italy. Electronic address: gmc@studiocalori.it.
• Injury. 2014 Feb 1;45(2):369-73.

ObjectiveTo determine the efficacy of core decompression (CD) technique combined with recombinant morphogenetic proteins, autologous mesenchymal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head.Patients And MethodsA total of 38 patients (40 hips) with early stage osteonecrosis of the femoral head were studied over a 4-year period.ResultsCD technique combined with recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute was associated with a significant reduction in both pain and joint symptoms and reduced the incidence of fractural stages. At 36 months, 33 patients achieved clinical and radiographic healing.ConclusionThis long-term follow-up study confirmed that CD technique combined with recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute may be an effective treatment for patients with early stage osteonecrosis of the femoral head.Copyright © 2013 Elsevier Ltd. All rights reserved.

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