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Nature neuroscience · Apr 2015
The dorsal posterior insula subserves a fundamental role in human pain.
- Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar, and Irene Tracey.
- 1] Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK. [2] Nuffield Division of Anesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
- Nat. Neurosci. 2015 Apr 1;18(4):499-500.
AbstractSeveral brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.
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