• Clin. Pharmacol. Ther. · Jul 2014

    Review

    Warfarin pharmacogenetics: to genotype or not to genotype, that is the question.

    • L H Cavallari and E A Nutescu.
    • Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, USA.
    • Clin. Pharmacol. Ther. 2014 Jul 1;96(1):22-4.

    AbstractGenotype is well recognized to influence the dose of warfarin necessary for therapeutic anticoagulation. Recent randomized controlled trials evaluating the clinical utility of genotype-guided warfarin dosing have produced varying results. We review the design and results of the recent clinical trials, assess the impact of their findings on warfarin dosing, and examine unanswered questions related to clinical implementation of warfarin pharmacogenetics.

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