• Ronan M G Berg, Ronni R Plovsing, Kevin A Evans, Claus B Christiansen, Damian M Bailey, Niels-Henrik Holstein-Rathlou, and Kirsten Møller.
• Crit Care. 2013 Oct 16; 17 (5): R238R238.

IntroductionSepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.MethodsA total of ten healthy volunteers were exposed to acute isocapnic inspiratory hyperoxia (FIO₂ = 40%) and hypoxia (FIO₂ = 12%) before and after a 4-hour lipopolysaccharide (LPS) infusion (2 ng kg-1). Middle cerebral artery blood follow velocity was assessed using transcranial Doppler ultrasound, and dynamic autoregulation was evaluated by transfer function analysis.ResultsTransfer function analysis revealed an increase in the phase difference between mean arterial blood pressure and middle cerebral artery blood flow velocity in the low frequency range (0.07-0.20 Hz) after LPS (P<0.01). In contrast, there were no effects of either isocapnic hyperoxia or hypoxia on dynamic autoregulation, and the cerebral oxygen vasoreactivity to both hyperoxia and hypoxia was unaffected by LPS.ConclusionsThe observed increase in phase suggests that dynamic cerebral autoregulation is enhanced after LPS infusion and resistant to any effects of acute hypoxia; this may protect the brain from ischaemia and/or blood-brain barrier damage during the early stages of sepsis.

30 keywords...

hide…