• Kyokun Uehara, Koji Ueyama, Hidehiro Ito, Terunobu Fukuda, Kenichi Sasaki, Tomomi Abe, Eisaku Nakane, Shoichi Miyamoto, Tetsuya Haruna, Moriaki Inoko, and Ryuji Nohara.
• Department of Surgery, Cardiovascular Center, Kitano Hospital, Osaka, Japan.
• Kyobu Geka. 2010 Mar 1;63(3):188-91.

AbstractAtrial fibrillation following cardiac surgery remains as a most common complication. Tachycardia with atrial fibrillation just after the operation could lead to cardiac deterioration. Although we have to control tachycardia, we often have great difficulties in managing these arrhythmias. Many reports have showed landiolol, ultra short-acting beta1 blocker, and amiodarone were effective against postoperative atrial fibrillation. However there has been no report on comparison between these 2 drugs. As excessively sympathetic activity might cause atrial fibrillation, landiolol was introduced into our therapy concomitant with the sedative. Our investigation confirmed that both landiolol and amiodarone were effective in preventing atrial fibrillation, and that the timing of transition from intravenous administration to oral intake was acceptable. When landiolol was administered, enough attention should be paid to the patients whose left ventricular function was low. The patients in whom atrial fibrillation occurred under landiolol therapy showed tendency of lower heart rate in comparison with the patients under amiodarone therapy.

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