• Miho Nakamura, Hidetoshi Nakamura, Naoto Minematsu, Shotaro Chubachi, Masaki Miyazaki, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Shuko Mashimo, Saeko Takahashi, Takahiro Nakajima, Hiroki Tateno, Seitaro Fujishima, and Tomoko Betsuyaku.
• Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine , Tokyo , Japan .
• Biomarkers. 2014 Aug 1;19(5):368-77.

AbstractChronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

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