αII-spectrin breakdown products (SBDPs): diagnosis and

Journal of neurotrauma · Jul 2010

αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients.

In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyzed 40 adult patients with severe TBI (Glasgow Coma Scale [GCS] score 6 ng/mL) and SBDP120 levels (>17.55 ng/mL) strongly predicted death (odds ratio 5.9 for SBDP145, and 18.34 for SBDP120). The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment.

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- Stefania Mondello, Steven A Robicsek, Andrea Gabrielli, Gretchen M Brophy, Linda Papa, Joseph Tepas, Claudia Robertson, Andras Buki, Dancia Scharf, Mo Jixiang, Linnet Akinyi, Uwe Muller, Kevin K W Wang, and Ronald L Hayes.
- Department of Clinical Programs and Center of Innovative Research, University of Florida, Gainesville, Florida, USA.
- J. Neurotrauma. 2010 Jul 1; 27 (7): 120312131203-13.
AbstractIn this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyzed 40 adult patients with severe TBI (Glasgow Coma Scale [GCS] score 6 ng/mL) and SBDP120 levels (>17.55 ng/mL) strongly predicted death (odds ratio 5.9 for SBDP145, and 18.34 for SBDP120). The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment.

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αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients.

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