• Amyloid · Jan 2009

    Case Reports

    Marked shrinkage of amyloid lymphadenopathy after an intensive chemotherapy in a patient with IgM-associated AL amyloidosis.

    • Ko-Ichi Tazawa, Nagaaki Katoh, Yasuhiro Shimojima, Masayuki Matsuda, and Shu-Ichi Ikeda.
    • Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
    • Amyloid. 2009 Jan 1;16(3):183-5.

    AbstractA male patient with primary AL amyloidosis who had been suffering from systemic lymphadenopathy with IgMkappa-type M-proteinemia received two courses of VAD and high-dose melphalan with in vivo elimination of CD20(+) cells using rituximab followed by autologous peripheral blood stem cell transplantation. Four years after complete hematological remission he showed marked reduction in size of the amyloid-laden lymph nodes. Deposits of AL amyloid may regress from the tissue if the chemotherapy succeeds in persistent inhibition of the production of amyloidogenic immunoglobulin light chains.

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