• Obstetrics and gynecology · Sep 2006

    Case Reports

    Massive subchorionic hematoma associated with enoxaparin.

    • Richard H Lee and T Murphy Goodwin.
    • Los Angeles County-University of Southern California Medical Center, Women's and Children's Hospital, Los Angeles, CA 90033, USA. richardl@usc.edu
    • Obstet Gynecol. 2006 Sep 1;108(3 Pt 2):787-9.

    BackgroundThe use of low-molecular-weight heparins is increasing for the prevention of thromboembolism in pregnancy. Subchorionic hematoma as a complication of anticoagulation therapy is rarely reported.CaseA persistent, massive subchorionic hematoma was diagnosed in a pregnant patient with atrial fibrillation and mitral stenosis. Enoxaparin was administered to maintain her trough anti-Xa level 0.5 units/mL or higher. The patient's peak anti-Xa levels never exceeded 1.05 units/mL. The patient underwent cesarean delivery at 34 6/7 weeks of gestation for preterm premature rupture of membranes.ConclusionSubchorionic hematoma is a potentially serious complication that can occur in pregnant patients receiving enoxaparin for the prevention of thromboembolism.

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