• Revista médica de Chile · Jun 1999

    Randomized Controlled Trial Clinical Trial

    [Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients].

    • G Hernández, J Gigoux, G Bugedo, L Castillo, A Bruhn, V Tomicic, and J Dagnino.
    • Departamento de Anestesiología, Facultad de Medicina, Pontificia Universidad Católica de Chile.
    • Rev Med Chil. 1999 Jun 1;127(6):660-6.

    BackgroundVasoactive drugs used in the reanimation of septic patients, can modify splanchnic perfusion.AimTo compare the effects of dobutamine and amrinone on gastric intramucosal pH (pHi), lactate levels and hemodynamics in surgical patients with compensated septic shock.Patients And MethodsFourteen postoperative patients with abdominal sepsis and compensated septic shock (pHi < 7.32 or lactate > 2.5 mmol/l) were studied in a prospective, randomized, unblinded study. Patients were randomized to receive (Group 1, n = 7) dobutamine at 5 micrograms/Kg/min or (Group 2, n = 7) amrinone at 5 micrograms/Kg/min. Hemodynamic data, arterial lactate and pHi were measured before and 30, 60 and 120 minutes after starting drug infusion.ResultsBoth drugs were associated with a decrease in lactate levels. Dobutamine infusion, but not amrinone, increased gastric pHi, as well as cardiac index and oxygen delivery.ConclusionsAn improvement in gastric pHi associated with an increase in oxygen delivery, was observed with dobutamine. Amrinone showed no effect at the fixed, low dose used in the study.

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