• Eur J Anaesthesiol · Aug 2014

    Randomized Controlled Trial

    Dexamethasone decreases the duration of rocuronium-induced neuromuscular block: A randomised controlled study.

    • Stefan Soltész, Patrick Fraisl, Karl Günter Noé, Jochen Hinkelbein, Hermann Mellinghoff, and Thomas Mencke.
    • From the Department of Anaesthesia and Intensive Care (SS, PF) and the Department of Gynaecology (KGN), KKH Dormagen, Dormagen, the Department of Anaesthesia and Intensive Care, University of Cologne, Cologne (JH, HM) and the Department of Anaesthesia and Intensive Care Medicine, University of Rostock, Rostock, Germany (TM).
    • Eur J Anaesthesiol. 2014 Aug 1;31(8):417-22.

    BackgroundSeveral drugs influence the time course of neuromuscular block during general anaesthesia.ObjectiveTo evaluate the effect of a single dose of dexamethasone 8 mg on the time course of a rocuronium-induced neuromuscular block.DesignA randomised controlled, unblinded, monocentre trial.SettingKreiskrankenhaus Dormagen, Dormagen, Germany.PatientsOne hundred and eight adult patients scheduled for elective gynaecological laparoscopic surgery allocated to three groups.InterventionsPatients received dexamethasone 8 mg intravenously 2 to 3 h prior to surgery (Group A), during induction of anaesthesia (Group B) or after recovery of the neuromuscular block (Group C, control).Main Outcome MeasuresThe time course of the neuromuscular block of rocuronium 0.3 mg kg was assessed using acceleromyography. The primary end point was the time from start of injection of rocuronium until recovery to a train-of-four ratio of 0.9.ResultsThe clinical duration was decreased in Group A (15.8 ± 4.5 min) compared with Group B (18.7 ± 5.8 min; P = 0.031). The recovery index was reduced in Group A (6.8 ± 1.8 min) compared with Group B (8.1 ± 2.6 min; P = 0.018) and Group C (8.3 ± 2.8 min; P = 0.01). The recovery to a train-of-four ratio of 0.9 was shorter in Group A (30.4 ± 6.9 min) than in Groups B (36.3 ± 10.7 min; P = 0.031) and C (36.8 ± 11.3 min; P = 0.02).ConclusionA single dose of dexamethasone 8 mg attenuated rocuronium-induced block by 15 to 20% if administered 2 to 3 h prior to induction of anaesthesia. However, the administration of dexamethasone during induction of anaesthesia did not influence the time course of the neuromuscular block.Trial RegistrationClinicalTrial.gov Identifier: NCT01782820.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.