• Nephrol. Dial. Transplant. · Aug 2010

    Review Case Reports

    Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus.

    • Huseyin Kadikoy, Michael Paolini, Katafan Achkar, Wadi Suki, A Osama Gaber, Nabeel Anwar, Abdallah Jeroudi, Roberto Barrios, and Abdul Abdellatif.
    • Department of Medicine, Baylor College of Medicine, Houston, TX, USA. hkadikoy@gmail.com
    • Nephrol. Dial. Transplant. 2010 Aug 1;25(8):2795-8.

    AbstractPulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

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