• Kathryn M Brennan, Yunhong Bai, and Michael E Shy.
• Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa, IA 52242, USA. Electronic address: kathryn-brennan@uiowa.edu.
• Neurosci. Lett. 2015 Jun 2;596:14-26.

AbstractInherited neuropathies known collectively as Charcot-Marie-Tooth disease are one of the most common inherited neurological conditions affecting ∼1 in 2500 people. A heterogenous disorder, CMT is divided into subtypes based on the pattern of inheritance and also by neurophysiological studies. Despite the clinical similarities among patients with demyelinating CMT, it is recognized that this group of disorders is both genetically and phenotypically heterogenous. Understanding the pathogenesis of these disorders requires an intimate knowledge of normal myelin development and homeostasis. Improvements in genetic testing techniques over the last 20 years have contributed majorly to the identification of specific genes, proteins, and molecular pathways that are providing the basis for understanding the disease processes and developing rational approaches to therapy.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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