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- Herminia L Buchelli Ramirez, Celso M Álvarez Álvarez, José J Rodríguez Reguero, Marta M García Clemente, and Pere Casan Clarà.
- Pneumology Department.
- Respir Care. 2014 May 1;59(5):e77-80.
AbstractPulmonary arterial hypertension and secondary pleural effusion have been reported in association with long-term therapy with the multi-tyrosine kinase inhibitor dasatinib, approved for the treatment of chronic myeloid leukemia. Here, we present the case of a 50-year-old man, diagnosed with chronic myeloid leukemia in August 2003, who developed pulmonary arterial hypertension after > 4 years of treatment with dasatinib. The complete remission of pulmonary arterial hypertension following dasatinib discontinuation suggests an etiological role of the drug in its development, although the administration of sildenafil may have played a therapeutic role.
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