• J B Chadduck, J R Sneyd, and L H Pobereskin.
• Department of Neurosurgery, University of Virginia, Charlottesville, USA.
• J. Neurosurg. 1999 Jan 1;90(1 Suppl):67-72.

ObjectThe authors studied the effect of immediate postoperative administration of bupivacaine in patients who underwent a lumbar decompressive procedure.MethodsIn this randomized double-blind trial, 50 patients who underwent elective lumbar decompression after induction of general anesthetic received a postoperative bilateral paravertebral 40-ml intramuscular application of either saline (0.9%) or bupivacaine (0.25%). For delivering morphine, both groups used a patient-controlled analgesia system for 24 hours postsurgery. Pain scores, 10-cm visual analog scale scores, and morphine consumption were similar between groups with no significant differences (p>0.05).ConclusionsResults of subgroup analysis suggested strongly that perioperative administration of methylprednisolone in a sustained-release preparation was associated with a reduction in postoperative pain (p<0.05).

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