• Fernando Pico, Julien Labreuche, Jean-Jacques Hauw, Danielle Seilhean, Charles Duyckaerts, and Pierre Amarenco.
• From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
• Stroke. 2016 Jan 1; 47 (1): 224-7.

Background And PurposeIntracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series.MethodsSixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol.ResultsCoronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE (P=0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r=0.51; P=0.003 and coronary artery ectasia patients, P=0.006).ConclusionsThis autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.© 2015 American Heart Association, Inc.

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