• Viviane Slon, Nathan Peled, Janan Abbas, Dan Stein, Haim Cohen, and Israel Hershkovitz.
• *Department of Anatomy and Anthropology, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel †Department of Radiology, Carmel Medical Center, Haifa, Israel ‡Department of Physical Therapy, Zefat Academic College, Zefat, Israel.
• Spine. 2016 Apr 1; 41 (8): E481-8.

Study DesignThis cross-sectional study was carried out on 196 adults (98 men and 98 women), aged between 18 and 91 years.ObjectiveTo examine whether vertebral hemangiomas (VHs) are associated with other spinal pathologies, metabolic diseases, cardiovascular diseases, cancer and past trauma, to shed light on their possible pathophysiology.Summary Of Background DataVHs are the most common form of benign tumors in the spine. Their association with spinal and systemic pathologies has not yet been systematically studied.MethodsClinical data were gathered from full spine CT scans and medical records.ResultsVHs were significantly associated with disc lesions (P = 0.004), past trauma (P = 0.037), diabetes (χ = 5.179, P = 0.023), cardio-vascular diseases (χ = 8.625, P = 0.003), and cancer (χ = 5.820, P = 0.016), but not with obesity. Only medium-large size VHs were significantly associated with osteoporosis (χ = 6.695, P = 0.010).ConclusionThe pattern of diseases related to VHs suggests a common cause for VH, namely, a disruption of vascular flow in the microvessels (accompanied by endothelium damage) within the vertebral body, eventually resulting in hypervascularization.Level Of Evidence4.

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