• Osama A Albirmawy, Magdy E Saafan, Emad M Shehata, Ahmed S Basuni, and Ahmed A Eldaba.
• Otolaryngology Department, Tanta University Hospital, Egypt. albirmawy@hotmail.com
• Int. J. Pediatr. Otorhinolaryngol. 2013 Jul 1;77(7):1139-42.

ObjectiveIs to evaluate the efficacy of tranexamic acid when applied locally in children after primary isolated adenoidectomy with respect to intra-operative blood loss and post-operative bleeding.Study DesignProspective, double-blind, randomized, controlled trial.SettingOtolaryngology department, Tanta University and Tiba Hospitals, Egypt.Patients And MethodsOver three years, 400 children underwent primary isolated adenoidectomy followed by topical application of tranexamic acid (tranexamic acid group, 200 children) or saline (Placebo group, 200 children) with at least two weeks' follow up. Intra-operative blood loss and post-operative hemorrhage were monitored.ResultsBoth groups were almost equivalent in age and gender. The frequency of primary post-adenoidectomy hemorrhage as well as the rate of postnasal packing and blood transfusion required to manage severe bleeding were higher in placebo group. The volume of blood loss during surgery showed significant reduction in tranexamic acid group.ConclusionTopical application of tranexamic acid after adenoidectomy led to a significant reduction in blood loss during surgery and decreasing in the rate of post-operative bleeding as well as the need for postnasal packing and blood transfusion.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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