• Expert Opin Pharmacother · Dec 2008

    Clinical Trial

    Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy.

    • Qingqing Cai, Huiqiang Huang, Xiaofei Sun, Zhongjun Xia, Yuhong Li, Xubin Lin, and Ying Guo.
    • Sun Yat-sen University, Cancer Center, Guangzhou, Department of Medical Oncology, State Key Laboratory of Oncology in Southern China, 651 E. Dongfeng Road, Guangzhou, 510060, PR China.
    • Expert Opin Pharmacother. 2008 Dec 1;9(18):3137-44.

    Background/ObjectiveWe investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy.MethodsThirty-two patients who had moderate to severe pain using the Numeric Rating Scale (NRS) were enrolled in this study. The analgesic effect, quality of life and side effects were evaluated after the administration of transdermal fentanyl.ResultsThe median NRS score was reduced from 6 (range 4 - 9) before treatment to 4 (range 0 - 9), 2.5 (range 0 - 8), 2 (range 0 - 8), 2 (range 0 - 6) and 0 (range 0 - 5) on days 3, 5, 7, 10 and 15, respectively, after treatment (p < 0.001). The patients' quality of life also improved significantly (p < 0.01). The side effects of treatment were mild, and disappeared within several days.ConclusionsTransdermal fentanyl is an effective, convenient and well-tolerated treatment for severe mucositis pain caused by chemotherapy that can improve patients' quality of life.

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