• Eur J Anaesthesiol · Jul 1998

    Thiopentone and propofol: a compatible mixture?

    • H G Paw, M Garrood, A J Fillery-Travis, and G T Rich.
    • Department of Anaesthesia, James Paget Hospital, Gorleston, Great Yarmouth, UK.
    • Eur J Anaesthesiol. 1998 Jul 1;15(4):409-13.

    AbstractThe physical compatibility of thiopentone and propofol mixtures was investigated. The investigations used were macroscopic and microscopic observations, zeta potential and oil droplet size measurements. There was no evidence of instability in the mixtures. The thiopentone-propofol mixture has the potential advantage of reducing the pain on injection, provides synergistic interaction, does not prolong recovery when used for induction of anaesthesia, may reduce the incidence of convulsions and is cost-effective.

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