• Miklos D Kertai, Eric Boersma, Jeroen J Bax, Ian R Thomson, Maarten J Cramer, Louis L M van de Ven, Michaël G Scheffer, Giuseppe Trocino, Carlo Vigna, Hubert F Baars, Hero van Urk, Jos R T C Roelandt, Don Poldermans, and Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) Study Group.
• Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
• Arch Intern Med. 2003 Oct 13;163(18):2230-5.

BackgroundSurvivors of major vascular surgery are at increased risk of late cardiac complications.ObjectiveTo examine the cardioprotective effect of beta-blockers.MethodsA follow-up study was conducted in 1286 patients who survived surgery for at least 30 days. Patients were screened for cardiac risk factors and dobutamine stress echocardiography (DSE) results; 1034 patients (80%) underwent preoperative DSE, and 370 (29%) received beta-blockers. The main outcome measure was late cardiac death or myocardial infarction.ResultsSeventy-four patients (5.8%) had late cardiac events. Cardiac event rates in patients with 0, 1 to 2, and 3 or more risk factors were 1.6%, 4.7%, and 19.2%, respectively. In patients without risk factors, beta-blockers were associated with improved event-free survival (2.8% vs 0%), and DSE had no additional prognostic value. In patients with 1 to 2 risk factors, the presence of ischemia during DSE increased cardiac events from 3.9% to 9.8%. However, if patients with ischemia were treated with beta-blockers, the risk decreased to 7.2%. In patients with 3 or more risk factors, DSE and beta-blockers stratified patients into intermediate- and high-risk groups. In patients without ischemia, beta-blockers reduced the cardiac event rate from 15.1% to 9.5%, whereas the cardioprotective effect was limited in patients with 3 or more risk factors and positive DSE findings.ConclusionsLong-term beta-blocker use is associated with a reduction in the cardiac event rate, except for patients with 3 or more risk factors and positive findings on DSE.

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