• Antoine Roch, Sami Hraiech, Elodie Masson, Dominique Grisoli, Jean-Marie Forel, Mohamed Boucekine, Pierre Morera, Christophe Guervilly, Mélanie Adda, Stéphanie Dizier, Richard Toesca, Fréderic Collart, and Laurent Papazian.
• URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, Aix Marseille Université, 13005, Marseille, France, antoine.roch@ap-hm.fr.
• Intensive Care Med. 2014 Jan 1; 40 (1): 74-83.

PurposePatients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. The evaluation of organ severity is difficult in patients considered for cannulation in a distant hospital. This study was designed to identify early factors associated with hospital mortality in ARDS patients treated with ECMO and retrieved from referring hospitals.MethodsData from 85 consecutive ARDS patients equipped with ECMO by our mobile team and consequently admitted to our ICU were prospectively collected and analyzed.ResultsThe main ARDS etiologies were community-acquired bacterial pneumonia (35%), influenza pneumonia (23%) (with 12 patients having been treated during the first half of the study period), and nosocomial pneumonia (14%). The median (interquartile range) time between contact from the referring hospital and patient cannulation was 3 (1-4) h. ECMO was venovenous in 77 (91%) patients. No complications occurred during transport by our mobile unit. Forty-eight patients died at the hospital (56%). Based on a multivariate logistic regression, a score including age, SOFA score, and a diagnosis of influenza pneumonia was constructed. The probability of hospital mortality following ECMO initiation was 40% in the 0-2 score class (n = 58) and 93% in the 3-4 score class (n = 27). Patients with an influenza pneumonia diagnosis and a SOFA score before ECMO of less than 12 had a mortality rate of 22%.ConclusionsAge, SOFA score, and a diagnosis of influenza may be used to accurately evaluate the risk of death in ARDS patients considered for retrieval under ECMO from distant hospitals.

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