• Jonas Hallén, Peter Petzelbauer, Jürg Schwitter, Bernard Geudelin, Peter Buser, and Dan Atar.
• Department of Cardiology, Oslo University Hospital, Aker and University of Oslo, Norway. jonahall@medisin.uio.no <jonahall@medisin.uio.no>
• EuroIntervention. 2010 Apr 1; 5 (8): 946-52.

AimsTo determine whether the efficacy of FX06 was dependent upon the timing of reperfusion therapy or the presence of collaterals in the Efficacy of FX06 in the prevention of myocardial reperfusion injury (F.I.R.E.) trial.Methods And ResultsTwo hundred and thirty-four (234) patients presenting with acute ST-segment elevation myocardial infarction were randomised to FX06 or matching placebo given as an intravenous bolus at reperfusion. Infarct size was assessed at 5-7 days and four months after myocardial infarction by cardiac magnetic resonance imaging determined total late enhancement and necrotic core zone. Patients were stratified according to presentation status (time-to-therapy <3 hours, n=108; time-to-therapy=3-6 hours, n=115) and presence of collaterals (yes, 46; no, 177). There were no statistically significant differences between groups at day 5-7. At four months, we observed statistically significant reductions of both measures of infarct size (0.3% vs. 2.4%, p=0.038; 8.0% vs. 16.0%, p=0.032) in the group given FX06 and presenting early. There was also a statistically significant reduction of total late enhancement zone among patients given FX06 with collaterals (7.3% vs. 15.2%, p=0.043). No differences were evident among late presenters or those without collaterals.ConclusionsFX06 significantly reduced infarct size at four months in the early presenters and in those with collaterals.

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